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EC number: 232-092-5
CAS number: 7786-17-6
Table 1 Net Gain in
Net Gain in Bodyweight (g)
The potential of the test material to cause toxicity via the dermal
route was assessed in the albino rabbit.
The depilated trunk of 11 rabbits was exposed to large doses of the test
material for a period of 24 hours in an occlusive fashion. A single
rabbit was treated with a dose of 8 mL/kg bw; 10 rabbits were treated
with a dose of 16 mL/kg bw. Exposure was followed by a
14 day observation period.
No signs of systemic toxicity were observed. Behaviour, appearance and
bodyweights (with the exception of 1 animal) were completely normal
throughout the study. Some transient skin irritation was observed
however this was completely reversed within 4 to 7 days.
The test material was found to be not systemically toxic to the rabbit
at doses of 8 and 16 mL/kg (equivalent to 7560 and 15120 mg/kg bw,
respectively). The LD50 is considered to be greater than the highest
dose tested, 16 mL/kg bw (15120 mg/kg bw). Under the conditions of the
study, there is no requirement for the material to be classified in
accordance with EU criteria.
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