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Limited data are available on the toxicity of ATMP-xNH4to aquatic organisms. ATMP-xNH4will dissociate as it is released into the aquatic environment and it is therefore necessary to assess the hazard properties of ATMP and ammonia separately. For hazard classification the substance has been assessed as a preparation, i.e. on the basis of the proportions of ATMP acid and ammonia that are present, as stipulated in its Annex I (DSD)/Annex VI (CLP) entry.

A 96 h LC50 value of 160 mg/L (as active acid) has been determined for the effects of ATMP acid (CAS 6419-19-8) on mortality of the freshwater fish Salmo gairdneri (now known as Onychorhynchus mykiss). A 14 day LC50 of 150 mg active acid/L and NOEC of 47 mg active acid/L have also been determined for the effects of the same substance on mortality of S. gairdneri.

A 96 h LC50 value of >282 mg/L (as active acid) has also been determined for the effects of ATMP on mortality of the marine fish Cyprinodon variegatus. The result was obtained in a test conducted with ATMP 5Na salt (CAS 2235-43-0) and the result has been expressed relative to the concentration of ATMP acid.

Under CLP ammonia is classified as Acute hazard 1 for aquatic toxicity.

A 60-d NOEC of 23 mg/L (as active acid) has been determined for the effects ATMP acid (CAS 6419-19-8) on growth of the freshwater fish Oncorhynchus mykiss.

The category hypothesis is that all the members are various ionised forms of the acid 6419-19-8. The main assumption is that sodium and potassium are not significant in respect of all the properties under consideration. ATMP-xNH4 will dissociate into ATMP and ammonia in the route of administration in oral exposures (food), therefore the two substances must be assessed separately. In dilute aqueous conditions of defined pH a salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated. Hence some properties for a salt can be directly read-across (with suitable mass correction) to the parent acid and vice versa.