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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study report is limited to a single page with no methods, no description of the results or number of animals used. It simply states the study outcome. There are no other data available for this endpoint.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
Principles of method if other than guideline:
No information given on methods
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-aminobutan-1-ol
EC Number:
202-488-2
EC Name:
2-aminobutan-1-ol
Cas Number:
96-20-8
Molecular formula:
C4H11NO
IUPAC Name:
2-aminobutan-1-ol
Details on test material:
79.4% purity

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5 ml of test material as received
Duration of treatment / exposure:
4 Hours
Observation period:
Immediately after removal of Dressing
Number of animals:
6

Results and discussion

In vivo

Irritant / corrosive response data:
Only the corrosivity was determined, as such no information is provided on individual animal scores for erythema and edema. The conclusion of the assay was that the material tested was corrosive, however there is no information on the time taken to produce corrosivity, i.e. 4 mins, 1 hour or 4 hours.
Considering the pH and the irritancy of the structurally related compound 2-amino-2-methylpropanol it is likely that it is corrsoive at 4 hours rather than 1 hours

Any other information on results incl. tables

Only the corrosivity was determined, as such no information is provided on individual animal scores for erythema and edema. The conclusion of the assay was that the material tested was corrosive.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The substance appears to be corosive. Considering the high pH of the test material in a 0.1M aqueous solution (pH11.1) it is not surprising that the substance is corrosive.
Executive summary:

2 -Aminobutanol was tested for corrosivity using a Draize protocol, where 6 Albino Rabbits were exposed under occlusive conditions to the test material for 4 hours. Under the conditions of the assay the substance was Corrosive.