Registration Dossier
Registration Dossier
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EC number: 700-989-5 | CAS number: -
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study is rated a "4" because the study predates GLP and limited details are provided.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF, Jr, et al
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Assoc J 23:95-107
Materials and methods
- Principles of method if other than guideline:
- Method: other: Smyth H.F. et al. Am. Ind. Hyg. Assoc. J. 23:95-107
- GLP compliance:
- no
Test material
- Reference substance name:
- Di-''isodecyl'' phthalate
- EC Number:
- 247-977-1
- EC Name:
- Di-''isodecyl'' phthalate
- Cas Number:
- 26761-40-0
- Molecular formula:
- C28H46O4
- IUPAC Name:
- 1,2-benzenedicarboxylic acid, di-isodecyl ester
- Details on test material:
- IUCLID4 Test substance: other TS: unspecified DIDP isomer
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 4-5 wks of age
- Weight at study initiation: 90-120 g
- Diet (e.g. ad libitum): Rockland rat diet, complete
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- 14 day observation period following single dose administration
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 60 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- The test substance is assumed to have a low order of acute toxicity by the oral route.
- Executive summary:
The LD50 of DIDP in rats is greater than 62,080 mg/kg (Smyth et al., 1962).
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