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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1964-10-22
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Non-standard, no guideline study. No GLP. Very old study. Exposure time only 5 days.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Principles of method if other than guideline:
Method: other. BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(vinyloxy)cyclohexane
EC Number:
218-561-7
EC Name:
(vinyloxy)cyclohexane
Cas Number:
2182-55-0
Molecular formula:
C8H14O
IUPAC Name:
(ethenyloxy)cyclohexane
Test material form:
other: colourless liquid
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female
Details on test animals or test system and environmental conditions:
No details available

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: aqueous emulsion with tragacanth
Details on oral exposure:
A 5 % aqueous emulsion of the test item was administered in a dose of 0.5 mL/kg bw by oral gavage to two male and two female rabbits.
The test item was applied once daily at five consecutive days. The animals were observed until death.
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
five days
Frequency of treatment:
once daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 mL/kg of a 5 % aqueous emulsion
Basis:
no data
No. of animals per sex per dose:
2 males, 2 females
Control animals:
no

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Based on:
not specified
Sex:
not specified
Basis for effect level:
other: see sect. "Overall remarks"
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion