[No public or meaningful name is available]

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1975-03-18, 1975-03-27

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test substance was administered undiluted in the highest tolerable amount of 30 ml/kg bw to groups of 10 males and 10 females.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Reaction mass of (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate and 2-{4-[2-(4-{2-[2-(methacryloyloxy)ethoxy]ethoxy}phenyl)propan-2-yl]phenoxy}ethyl methacrylate

EC Number:

939-702-5

Molecular formula:

C23H24O4 (C2H4O)n

IUPAC Name:

Reaction mass of (1-methylethylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl) bismethacrylate and 2-{4-[2-(4-{2-[2-(methacryloyloxy)ethoxy]ethoxy}phenyl)propan-2-yl]phenoxy}ethyl methacrylate

Test material form:

liquid: viscous

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Institute's colony
- Age at study initiation: no data
- Weight at study initiation: males 104-225g, females 79-194g
- Fasting period before study: forr 18 hours prior dosing
- Housing: in groups of five in screen-bottomed stainless steel cages
- Diet (e.g. ad libitum): stock diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25°C
- Humidity (%): no data
- Air changes (per hr): no details, "well-ventilated" room
- Photoperiod (hrs dark / hrs light): no data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

no

Doses:

30 ml/kg (corresponding to 35 g/kg)

No. of animals per sex per dose:

10 males and 10 females per dose

Control animals:

no

Details on study design:

Animals were observed during 14 days for signs of intoxication.
Autopsies were carried out on the surviving animals at the end of the 14-days period.

Statistics:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD0

Effect level:

> 35 000 mg/kg bw

Based on:

act. ingr.

Remarks on result:

other: No mortality observed

Mortality:

No death occurred during the observation period.

Clinical signs:

other: None of the treated animals showed any reaction upon treatment.

Gross pathology:

At the end of the 14-days period the survivors revealed no gross pathological changes.

Other findings:

Obviously both materials are of a very low acute oral toxicity. No difference in acute toxicity was observed between two samples.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

According to these results, oral LD50 of test item is higher than 35 000 mg/kg bw in rats.

Executive summary:

Test substance was administered undiluted in the highest tolerable amount of 30 ml/kg bw (corresponding to 35 000 mg/kg bw) to groups of 10 males and 10 females. Animals were observed during 14 days for signs of intoxication. Autopsies were carried out on the surviving animals at the end of the 14-days period.

No death occurred during the observation period. None of the treated animals showed any reaction upon treatment. At the end of the 14-days period the survivors revealed no gross pathological changes. According to these results, oral LD50 of test item is higher than 35 000 mg/kg bw in rats.