Registration Dossier
Registration Dossier
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EC number: 604-453-0 | CAS number: 145022-45-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In the Ames test, EMIM Methansulfonat did not lead to a biologically relevant increase in the number of revertant colonies either without S9 mix or after adding a metabolizing system in two experiments carried out independently of each other (standard plate test and preincubation assay). Besides, the results of the negative as well as the positive controls performed in parallel corroborated the validity of this study, since the values fulfilled the acceptance criteria of this study. In this study with and without S9 mix, the number of revertant colonies in the negative controls was within the range of the historical negative control data for each tester strain. In addition, the positive control substances both with and without S9 mix induced a significant increase in the number of revertant colonies within the range of the historical positive control data or above. Thus, under the experimental conditions chosen, it was concluded that EMIM Methansulfonat is not a mutagenic test substance in the bacterial reverse mutation test in the absence and the presence of metabolic activation. [BASF SE, 2012]
Short description of key information:
EMIM Methansulfonat is not a mutagenic test substance in the Ames test in the absence and the presence of metabolic activation (OECD 471).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
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