Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Méthode CEE, B1
GLP compliance:
yes
Test type:
standard acute method

Test animals

Species:
other: Rat Sprague Dawley

Administration / exposure

Vehicle:
other: Huile de maïs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 100 mg/kg bw
95% CL:
1 800 - 2 800
Mortality:
Male: 1300 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2400 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 4200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 1300 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2400 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 4200 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
other: Signs of toxicity related to dose levels: A 4200 mg/kg une mort est survenue dans les 24 heures suivant l'administration du produit et les autres au 3ème jour. A 2400 mg/kg les morts sont survenues des jours 2 à 4. Les signes observés sont les suiva
Gross pathology:
Effects on organs:
L'observation macroscopique des organes a montré des
hémorragies de l'estomac, des poumons (1 animal) et du
thymus ainsi qu'une coloration du foie, des reins et tube
digestif.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU