Registration Dossier

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to EU/OECD guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. certificate)

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical monitoring:
yes

Results and discussion

Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
0.04 h-1
DT50:
19.72 h
pH:
4
Temp.:
55 °C
Hydrolysis rate constant:
0.06 h-1
DT50:
11.53 h
pH:
4
Temp.:
65 °C
Hydrolysis rate constant:
0.16 h-1
DT50:
4.35 h
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
0.03 h-1
DT50:
20.55 h
pH:
7
Temp.:
55 °C
Hydrolysis rate constant:
0.06 h-1
DT50:
11.71 h
pH:
7
Temp.:
65 °C
Hydrolysis rate constant:
0.16 h-1
DT50:
4.26 h
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0.02 h-1
DT50:
28.5 h
pH:
9
Temp.:
55 °C
Hydrolysis rate constant:
0.04 h-1
DT50:
15.62 h
pH:
9
Temp.:
65 °C
Hydrolysis rate constant:
0.12 h-1
DT50:
5.6 h

Any other information on results incl. tables

At pH 4 the half-life period was determined by extrapolating the results of the experiments at

50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 14.1 days.

At pH 7 the half-life period was determined by extrapolating the results of the experiments at

50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 16.4 days.

At pH 9 the half-life period was determined by extrapolating the results of the experiments at

50 °C, 55 °C and 65 °C to a temperature of 25°C. It was found to be 24.9 days.

Applicant's summary and conclusion