Registration Dossier
Registration Dossier
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EC number: 223-981-9 | CAS number: 4151-51-3
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: poisoning incident
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Perorale Intoxikation mit Isocyanat und Methylenchlorid
- Author:
- Bernoulli et al.
- Year:
- 1 978
- Bibliographic source:
- Schweiz. med. Wschr. 108, 866-868
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline available
Test material
- Reference substance name:
- Tris(p-isocyanatophenyl) thiophosphate
- EC Number:
- 223-981-9
- EC Name:
- Tris(p-isocyanatophenyl) thiophosphate
- Cas Number:
- 4151-51-3
- Molecular formula:
- C21H12N3O6PS
- IUPAC Name:
- O,O,O-tris-(4-isocyanatophenyl) thiophosphate
- Details on test material:
- - Name of test material (as cited in the publication): FANA-Härter R1 = Desnodur RF (thiophosphoric acid -tris-p-isocyanatophenylester 20% in methylene chloride, additionally diluted with methylene chloride by 20%)
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: one
- Sex: female
- Age: 21
- weight: 57 kg
- pregnant - Route of exposure:
- oral
- Reason of exposure:
- other: suicide attempt
- Exposure assessment:
- estimated
Results and discussion
- Clinical signs:
- Coma, bradycardia, leukocytosis and metabolic acidosis (these clinical signs were ascribed to the effect of methylene chloride)
Any other information on results incl. tables
Untoward reactions in pregnancy were not observed. Four months after intoxication the patient bears a healthy boy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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