Registration Dossier
Registration Dossier
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EC number: 610-868-8 | CAS number: 52603-48-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 June 2009
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ASTM procedure (designation: E1147-92)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 5-amino-3-methylthiophene-2,4-dicarbonitrile
- EC Number:
- 610-868-8
- Cas Number:
- 52603-48-2
- Molecular formula:
- C7N3H5S
- IUPAC Name:
- 5-amino-3-methylthiophene-2,4-dicarbonitrile
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 1.84
- Remarks on result:
- other: No information provided on temperature and pH at which the study was conducted.
- Details on results:
- Under the HPLC conditions summarized above, the test substance exhibits a retention time of 3.056/3.017 minutes or an average time of 3.037 minutes. The average difference between the retention time of the internal standard and test substance was found to be 12.143 minutes. The log of this value was utilized in Equation 1 to determine the value of Log Kow for the test substance. The log Kow for the test substance was determined to be 1.84.
Any other information on results incl. tables
No information provided on temperature and pH at which the study was conducted.
Applicant's summary and conclusion
- Conclusions:
- The test compound was found to have an octanol-water partition coefficient of 64.56 or a log Kow of 1.84.
- Executive summary:
In a partition coefficient study (KP06232009), the log partition coefficient (log Pow) was determined to be 1.84 according to ASTM method E1147-92.
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