Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 619-535-1 | CAS number: 68418-51-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 101 mg/m³
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- other: LD50
- Value:
- 5 050 mg/m³
- AF for dose response relationship:
- 10
- Justification:
- Starting point is an LC50
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The allometric scaling factor is not applicable with inhalation DNEL
- AF for other interspecies differences:
- 1
- Justification:
- A suggestion of 2.5 is suggested by ECHA TGD
- AF for intraspecies differences:
- 5
- Justification:
- For intraspecies variability
- AF for the quality of the whole database:
- 1
- Justification:
- Good standard of database.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 101 mg/m³
- Most sensitive endpoint:
- acute toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Dose descriptor starting point:
- other: LC50
- AF for dose response relationship:
- 10
- Justification:
- Starting point is an LC50
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The allometric scaling factor is not applicable with inhalation DNEL
- AF for other interspecies differences:
- 1
- Justification:
- A suggestion of 2.5 is suggested by ECHA TGD
- AF for intraspecies differences:
- 5
- Justification:
- For intraspecies variability
- AF for the quality of the whole database:
- 1
- Justification:
- Good standard of database.
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2 mg/kg bw/day
- Most sensitive endpoint:
- acute toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 500
- Modified dose descriptor starting point:
- other: LD50
- Value:
- 939.9 mg/kg bw/day
- AF for dose response relationship:
- 10
- Justification:
- Starting point is LD50
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Allometric scaling factor for rats compared to humans
- AF for other interspecies differences:
- 2.5
- Justification:
- 2.5 suggested by ECHA TGD
- AF for intraspecies differences:
- 5
- Justification:
- Intraspecies variability
- AF for the quality of the whole database:
- 1
- Justification:
- Good standard of data
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
The substance is imported as a monomer to be fully consumed under strictly controlled conditions.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
The substance is imported as a monomer to be fully consumed under strictly controlled conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
