Registration Dossier
Registration Dossier
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EC number: 411-220-5 | CAS number: 134701-20-5 CG 27-145
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 09.11.2001 - 14.12.2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 440 Uterotrophic Bioassay in rodents: A short-term screening test for oestrogenic properties
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- toxicity to reproduction / fertility
Test material
- Reference substance name:
- 2,4-dimethyl-6-(1-methyl-pentadecyl)phenol
- EC Number:
- 411-220-5
- EC Name:
- 2,4-dimethyl-6-(1-methyl-pentadecyl)phenol
- Cas Number:
- 134701-20-5
- Molecular formula:
- C24 H42 O
- IUPAC Name:
- 2-(hexadecan-2-yl)-4,6-dimethylphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk:APfSD (Wistar derived)
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- single oral dose once a day
- Post exposure period:
- 24 hrs
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 250, 500, 1000 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- The study consisted of one vehicle control, one positive control (17 ß-estradiol benzoate) and three treatment groups, with 10 female rats each group.
- Control animals:
- yes, concurrent vehicle
Results and discussion
Applicant's summary and conclusion
- Executive summary:
There was no evidence of a uterotropic response with the test substance.
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