Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
10-14 Jul 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Details on test material:
- Name of test material: (S)-1-Phenylpropylamine (CAS 3789-59-1)

Test animals

Species:
rabbit

Test system

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
3 min and 60 min
Number of animals:
1

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
3 min exposure
Basis:
animal #1
Time point:
other: mean 24, 48, 72 hrs
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: necrosis
Irritation parameter:
edema score
Remarks:
3 min exposure
Basis:
animal #1
Time point:
other: mean 24, 48, 72 hrs
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: necrosis

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information
Conclusions:
The test item caused full thickness necrosis after a 3 min-dermal exposure and therefore had to be classified as corrosive.