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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data have been obtained from publication relative to

Data source

Reference
Reference Type:
publication
Title:
Effect of dioctyl sodium sulfosuccinate on colonic fluid and electrolyte movement
Author:
Donowitz M, Binder HJ.
Year:
1975
Bibliographic source:
Gastroenterology. 1975 Oct;69(4):941-50.

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Executive summary:

Dioctyl Sodium Sulfosuccinate DSS produced water, sodium and chloride secretion into the in vivo rat cecum. This secretion readily reverted to net absorption following replacement of DSS by isotonic saline. In in vitro studies, DSS increased the short circuit current and diminished sodium absorption. DSS also significantly increased mucosal cyclic adenosine monophosphate levels. DSS stimulates fluid and electrolyte secretion which is mediated by increased mucosal cyclic adenosine 3':5' monophosphate.