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Toxicological information

Endpoint summary

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Description of key information

Toxikokinetic information is derived as far as possible from the physico-chemical properties and available toxicity studies. Based on the reactivity of the substance at the benzoyl function, no bioaccumulation is expected.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential

Additional information

The substance is in solid state and is practically not soluble in water. The vapour pressure is very low and the MMAD is 22 mm. The partition coefficient of 5.8 and the molecular weight of 418 g/mol indicate a potential of uptake by the body. The substance should have a certain chemical reactivity as indicated by the skin sensitising properties. Sensitising properties of chemicals are often related to nucleophilic addition to cysteine or lysine containing proteins. In this case, benzoyl Schiff base formation was identified as a mechanism for protein binding via the model “Protein binding by OASIS” of the OECD QSAR Toolbox v2.3. As no indication of toxicity up to the limit dose was observed upon subacte dosing and very little changes in heamatology and clincial chemistry uptake occured upon subchronic dosing, systemic uptake of the substance is probably low and the absorbed fraction is rapidly detoxified by conjugation with glutathione. Conjugates are generally of higher solubility and excreted via kidney or bile.

Considering the reactivity at the benzoyl group and the absence of significant findings upon subchronic dosing, bioaccumulation of the substance is not expected.