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EC number: 939-262-4 | CAS number: 85665-45-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48h EC50 = 4.2 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 4.2 mg/L
Additional information
Since no short-term data involving aquatic invertebrates are available for C8-14AS TEA (CAS 85665-45-8), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to other structurally related category members was conducted. Read-across data from the following alkyl sulfates was applied: C8AS Na (CAS 142-31-4), C10AS Na (CAS 142-87-0), C12AS Na (CAS 151-21-3), C14AS Na (CAS 1191-50-0), C12-14AS TEA (CAS 90583-18-9) and C12-14AS Na (CAS 85586-07-8). Toxicity of alkyl sulfates is dependent on the carbon chain length and the influence of the counter ion can be neglected.
One GLP short-term toxicity test with Daphnia magna performed according to OECD guideline 202 is available for C8AS Na (CAS 142-31-4; Neven 1993). Daphnids were exposed under semi-static conditions to five test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). Based on mobility of daphnids, the 48-hour EC50 value for C8AS Na (CAS 142-31-4) was determined to be above 100 mg/L (nominal concentration).
Two 24-hour tests with Daphnia magna are available for C10AS Na (CAS 142-87-0). The first non-GLP study was performed following an AFNOR T.90301 (1974) method (Lundahl and Cabridenc 1978). The obtained results showed that the 24-hour EC50 value was 800 mg/L (nominal concentrations). Analytical measurements are not available. The other non-GLP study with Daphnia magna followed a method described by Norme Francaise Homologue, 1983, NF T90-31 (Sanchez Leal 1991). The 24-hour EC50 value was 470 mg/L. Analytical check of the test concentrations was not provided. It is expected that the 48-hour EC50 value of C10AS Na (CAS 142-87-0) for aquatic invertebrates will be above 100 mg/L.
Moreover, a non-GLP test with Ceriodaphnia dubia is available for C12AS Na (CAS 151-21-3). Daphnids were exposed to six test concentrations of up to 101 mg/L (Lauth 1996a). The test was performed under flow-through conditions, no special guideline was followed. Mortality of daphnids was evaluated daily. The EC50 value determined for C12AS Na (CAS 151-21-3) after 48 hours of exposure was 5.55 mg/L.
Another non-GLP flow through test with Ceriodaphnia dubia is available for C14AS Na (CAS 1191-50-1; Lauth 1996b). The study was performed according to EPA-600/489/001 method. Ceriodapnia dubia was exposed to six concentrations up to 6.38 mg/L and mortality of daphnids was checked daily. The 48-hour LC 50 value for C14AS Na (CAS 1191-50-1) was 1.58 mg/L.
Additionally, one reliable study investigating toxic effects of C12-14AS TEA (CAS 90583-18-9) to Daphnia magna is available. The GLP study was performed according to DIN 38412, part 1, equivalent to OECD 202 (Scholz 1995). Inhibition of mobility of daphnids caused by the test substance was determined after 24 and 48 of static exposure to test substance up to 10 mg/L (nominal concentrations in agreement with measured concentration). The results showed that the 48-hour EC50 value for C12-14AS TEA (CAS 90583-18-9) was 7.1 mg a.i./L (nominal concentration).
Finally, a GLP study is available for C12-14AS Na (CAS 85586-07-8) according to EG Guideline 92/69/EWG. In this study Daphnia magna was exposed in a static system to five concentrations up to 10 mg/L (nominal concentration corresponding to 9.5 mg/L of measured concentration) of C12-14AS Na of 29.8% purity (in water). The 48-hour EC50 value of 4.7 mg a.i./L (nominal concentration) could be determined for C12-14AS Na (CAS 85586-07-8).
Due to structural and property similarities with the tested category members these results also can be used to determine the short-term toxicity to aquatic invertebrates of C8-14AS TEA (CAS 85665-45-8). For the calculation of an 48-hour EC50, short-term data available for the pure homologues C8AS Na (CAS 142-31-4), C10AS Na (CAS 142-87-0), C12AS Na (CAS 151-21-3) and C14AS Na (CAS 1191-50-0) were used. The composition of C8-14AS TEA (CAS 85665-45-8) used for the calculation was based on the normalized mean values of provided ranges: C8: 13.6%, C10: 13.6%, C12: 50%, C14: 22.7%. Using the additivity formula stipulated in EC Regulation 1272/2008, the 48-hour EC50 value of C8-14AS TEA (CAS 85665-45-8) for aquatic invertebrates is 4.2 mg/L.
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