Registration Dossier
Registration Dossier
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EC number: 939-238-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Based on the test results with Stearic acid, esters with methyl α-D-glucoside, no inhibition of oxygen consumption of Pseudomonas putida was observed. Therefore, the 1 h-EC50 of the test substance is higher than 10000 mg/L.
The value is supported by the data obtained in the study with read across substance Isostearic acid, esters with methyl α-D-glucoside. No significant inhibitory effects of the test item at 100 mg/L were observed; the deviations from the untreated controls were less than 15%. The EC50 could not be calculated because Isostearic acid, esters with methyl α-D-glucoside proved to be non-toxic. Therefore, the 3 h-EC50 value based on inhibition of respiration was > 100 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
The toxic effects of Stearic acid, esters with methyl α-D-glucoside (according to producer infromation 100% a.i.) on Pseudomonas putida according to DIN 38412 part 27 (Bacteria Respiration test, preliminary draft) was assessed by measuring the respiration rate after 1 hour at 0 and 10000 mg/L (nominal). No analytical control was performed.
Based on the study results Stearic acid, esters with methyl α-D-glucoside showed no inhibition of oxygen consumption of Pseudomonas putida. Therefore, the 1 h-EC50 of the test substance is higher than 10000 mg/L.
The absence of toxic effects of the substance on microorganisms was also determinedina 3 hour toxicity study conducted according to OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test) and EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test), the cultures of activated sludge of a predominantly domestic sewage treatment plant were exposed toIsostearic acid, esters with methyl α-D-glucoside at a nominal concentration of 100 mg/L under static conditions. No analytical control was performed.
The following information is taken into account for effects on aquatic micro-organisms for the derivation of PNEC:
Based on the results of the present study Isostearic acid, esters with methyl α-D-glucoside showed no significant inhibitory effect of the test item at 100 mg/L; the deviations from the untreated controls were less than 15%. The EC50 could not be calculated because Isostearic acid, esters with methyl α-D-glucoside proved to be non-toxic. Therefore the 3 h-EC50 value based on inhibition of respiration was >100 mg/L.
Unlike Stearic acid, esters with methyl α-D-glucoside, Isostearic acid, esters with methyl α-D-glucoside, as a branched chain, is known to be more critical in its toxicological impacts and can be understood as a worst case in this analogue approach.
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