Registration Dossier
Registration Dossier
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EC number: 255-288-2 | CAS number: 41272-40-6
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
MG was demonstrated to be cytotoxic to two cell lines of human origin.
Additional information
Malachite Green (MG) was demonstrated to be cytotoxic to two cell lines of human origin, whereas its major reduced metabolite found in fish, Leucomalachite Green (LG), was not. The HEp-2 cells were more sensitive than Caco-2 cells to MG toxic effects, probably for their lower metabolic capacity; so far, the latter represent the most relevant model to human exposure. Besides, also in these cellular models, MG reduces proliferation capability and impairs mitochondrial activity (Stammati et al. 2005).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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