Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

No mortalities were observed up to the limit dose of 2000 mg/kg bw in the acute oral and dermal toxicity studies (LD50 (oral, rat) > 2000 mg/kg bw; LD50 (dermal, rat) > 2000 mg/kg bw). No dermal irritation and no ocular irritation were observed in GLP OECD guideline skin and eye irritation studies. Furthermore, the substance is not sensitising to the skin. No adverse effects were observed in a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in rats up to the limit dose of 1000 mg/kg bw/day. No genotoxic effects were observed in three in vitro tests in bacteria and mammalian cells.

Therefore, due to the lack of adverse effects up to the respective limit doses no threshold was identified for any toxicological endpoint. Consequently, no DNELs for workers or the general population have been derived.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

No mortalities were observed up to the limit dose of 2000 mg/kg bw in the acute oral and dermal toxicity studies (LD50 (oral, rat) > 2000 mg/kg bw; LD50 (dermal, rat) > 2000 mg/kg bw). No dermal irritation and no ocular irritation were observed in GLP OECD guideline skin and eye irritation studies. Furthermore, the substance is not sensitising to the skin. No adverse effects were observed in a Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in rats up to the limit dose of 1000 mg/kg bw/day. No genotoxic effects were observed in three in vitro tests in bacteria and mammalian cells.

Therefore, due to the lack of adverse effects up to the respective limit doses no threshold was identified for any toxicological endpoint. Consequently, no DNELs for workers or the general population have been derived