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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
160 mg/kg bw/day
Additional information

Based on the similarity of the source material, Ashes (Residues), and the target material, Ashes (Residues), nonhazardous municipal solid waste, may be assumed that target material has identical or similar reproduction toxicity.


Short description of key information:
The administration of the source substance Ashes (residues) did not affect the mortality and health condition of males, females, mothers and pups; sperm motility, vitality, morphology of males, stage of the cell cycle in males spermatogenesis; body weight of mothers during gestation, development of mating and pregnancy; vitality and development of pups, distribution of sexes in litter, pathological examination of pups; macroscopic appearance and microscopic structure of reproduction organs of both sexes.
Negative effects on fertility manifested in: increased post-implantation loss at the dose level of 400 mg/kg/day.
At the dose level of 160 mg/kg/day the examinations did not detect adverse effects of the source substance on reproduction.

Effects on developmental toxicity

Description of key information
The administration of the source substance Ashes (residues) did not affect the mortality and health condition of males, females, mothers and pups; sperm motility, vitality, morphology of males, stage of the cell cycle in males spermatogenesis; body weight of mothers during gestation, development of mating and pregnancy; vitality and development of pups, distribution of sexes in litter, pathological examination of pups; macroscopic appearance and microscopic structure of reproduction organs of both sexes. 
Negative effects on fertility manifested in: decrease of number of pups at the dose level of 1000 mg/kg/day. 
At the dose levels 160 and 400 mg/kg/day no negative effects on pups were detected.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
400 mg/kg bw/day
Additional information

Based on the similarity of the source material, Ashes (Residues), and the target material, Ashes (Residues), nonhazardous municipal solid waste, may be assumed that target material has identical or similar developmental toxicity.

Justification for classification or non-classification

Currently information is not sufficiently conclusive to classification of the target substance Ashes (residues), nonhazardous municipal solid waste. Therefore Prenatal Developmental Toxicity Study (EU method B.31) was proposed for more detailed examination of developmental toxicity of this material.

Additional information