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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

oral: The acute oral LD50 was determined to be greater than 5000 mg/kg bw in rats.
inhalation: The acute LC50 after inhalation of a vapor was calculated to be 12.16 mg/L in rats.

Key value for chemical safety assessment

Acute toxicity: via inhalation route

Endpoint conclusion
Dose descriptor:
LC50
Value:
12 160 mg/m³ air

Additional information

Oral

The test article was administered in two dosage groups (2150 and 5000 mg/kg bw) to 10 rats (each group consisted of 5 male and 5 female rats). In both treatment groups mortality was observed: 1 male rat died in the lower dosage group and 2 female rats died in the high dosage group. The overall observation period was 14 days. The oral LD50 was determined to be greater than 5000 mg/kg bw. [BASF, 1984]

Inhalation

The test item was administered for 4 hours to rats in 5 different treatment groups and each test group consisted of 10 male and 10 female rats. The LC50 value was calculated to be 12.16 mg/L. [BASF, 1986] 
In an inhalation risk test with rats no mortality was observed when 12 animals were exposed for 3 minutes to an atmosphere that has been saturated at 20°C with the volatile part of the compound. Mortality occured after 10 min (1/6) exposure. After 60 minutes of
exposure all animals died. [BASF, 1985]

Justification for classification or non-classification

Classification for acute oral toxicity is not warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.

1,1-Dimethoxytrimethylamine is harmful after inhalation (EU: R22; GHS acute oral cat. 4, H332) according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008.