Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Not classified for skin, eye or respiratory irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

SYN545192 was only mildly irritating to the skin and mild-moderately irritating to the eyes, with transient signs of irritation that reversed after 48 hours (skin) or 7-10 days (eyes) post-treatment. No classification is justified for either end-point. Based on the mild-moderate skin and eye irriation properties and the lack of any specific signs of respiratory irritation in the acute inhalation toxicity study, SYN545192 is considered not to justify classification as a respiratory irritant.


Effects on skin irritation/corrosion: slightly irritating

Effects on eye irritation: moderately irritating

Justification for classification or non-classification

Skin corrosion/irritation: Based on the available information the substance does not meet the criteria for classification for "skin corrosion/irritation" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.2.2; reason for non-classification: conclusive but not sufficient for classification.

Serious eye damage/eye irritation: Based on the available information the substance does not meet the criteria for classification for "serious eye damage/eye irritation" under Regulation (EC) 1272/2008, Annex I, Part 3, 3.3.2; reason for non-classification: conclusive but not sufficient for classification.

Respiratory tract irritation: Based on the available information the substance does not meet the criteria for classification as "respiratory tract irritant" (specific target organ toxicity – single exposure) under Regulation (EC) 1272/2008, Annex I, Part 3, 3.8.2.2.1; reason for non-classification: conclusive but not sufficient for classification.