Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 229-633-2 | CAS number: 6635-20-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 6635-20-7
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:- EPI Suite (DERMWIN) Various versions of EPI Suite dating back from 1990-2004.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Data is from DEPA .
- GLP compliance:
- no
Test material
- Reference substance name:
- 5-nitrovanillin
- EC Number:
- 229-633-2
- EC Name:
- 5-nitrovanillin
- Cas Number:
- 6635-20-7
- Molecular formula:
- C8H7NO5
- IUPAC Name:
- 4-hydroxy-3-methoxy-5-nitrobenzaldehyde
- Details on test material:
- - Name of test material: 5-nitrovanillin
- Molecular formula: C8H7NO5
- Substance type: organic
- Physical state: Solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
Results and discussion
Percutaneous absorption
- Remarks on result:
- other: Dermal absorption:0.00600 mg/cm2/event (MODERATE)
Applicant's summary and conclusion
- Conclusions:
- Dermal absorption value of 5-nitrovanillin was estimated to be 0.00600 mg/cm2/event (Moderate).
- Executive summary:
Dermal absorption value of 5-nitrovanillin was estimated to be 0.00600 mg/cm2/event (Moderate).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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