Registration Dossier
Registration Dossier
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EC number: 200-064-1 | CAS number: 50-78-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Summary on IUCLID (HEDSET) in existing Chemicals
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Monsanto
- Year:
- 2 000
- Bibliographic source:
- Summary on IUCLID (HEDSET) in existing Chemicals
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- O-acetylsalicylic acid
- EC Number:
- 200-064-1
- EC Name:
- O-acetylsalicylic acid
- Cas Number:
- 50-78-2
- Molecular formula:
- C9H8O4
- IUPAC Name:
- 2-acetoxybenzoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Dutch
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- semiocclusive
- Duration of exposure:
- 24 hours
- Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 940
- Based on:
- test mat.
Any other information on results incl. tables
Certainly combined with the dermal corrosion irritation assay
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- ASA is not toxic by dermal application on rabbit. This confirm the low dermal penetration.
- Executive summary:
With an LD50 > 7940 mg/kg in rabbit, ASA is not classified and did not justify any further study with rat.
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