Registration Dossier
Registration Dossier
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EC number: 200-064-1 | CAS number: 50-78-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Two reliability 2 publications and one supporting reliability 2 company study are available, and supported by a number of data cited in one of publications. Only one publication (Marques et al. 2004) and the company study, report for pH controls. The EC50 48h obtained with pH neutralized has therefore been selected for freshwater. Only one marine water species has been assessed, without precision about pH, but evertheless selected as reliable result by weight of evidence.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 290 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 380 mg/L
Additional information
Marques et al. 2004, have reported an EC50 48h in Daphnia magna for a study performed according to OECD guideline (version 1992), based on acetylsalicylic acid test solutions prepared fom a stock solution neutralized to pH 6 to 9. The EC50 24h reported by the company study were obtained from both neutralized and non-neutralized solutions: > 1000 and 330 mg/L respectively. These results support the EC50 48h by Marques et al. 2004. Marques et al. 2004 reported also that after 48 h, the EC50 for another species: Daphnia longispina, tested in parallel, (647.31 mg/L) was about half that determined for D. magna (1293.05 mg/L), though this was not a statistically significant difference once D. magna CL included the D.longispina EC50 value. So the D. magna EC50 was retained as key value.
No other study reports for pH controls. So toxicity observed cannot be attributed to both effects of acidity and substance toxicity, or substance toxicity alone. These EC50 range from 88 to 1470 mg/L in Daphnia magna. Cyst-based toxicity tests (in Brachionus calyciflorus and Streptocephalus proboscideus in freswater, and Artemia salina in marine water) confirmed the above values for the neutralized substance. Therefore the marine water EC50 was retained, despite lack on information on pH.
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