Registration Dossier
Registration Dossier
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EC number: 609-962-1 | CAS number: 41851-59-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to the results of the present study, the test substance rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) did not lead to an increase in the number of revertant colonies either without S9 mix or after adding a metabolizing system in two experiments carried out independently of each other (standard plate test and preincubation assay). Besides, the results of the negative as well as the positive controls performed in parallel corroborated the validity of this study, since the values fulfilled the acceptance criteria of this study. In this study with and without S9 mix, the number of revertant colonies in the negative controls was within the range of the historical negative control data for each tester strain. In addition, the positive control substances both with and without S9 mix induced a significant increase in the number of revertant colonies within the range of the historical positive control data or above.
Short description of key information:
The test substance rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) is not mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay (OECD 471).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available data for rac-1-(3-Methoxyphenyl)ethylamine (read across, CAS 62409-13-6) (S)-1-(4-Methoxyphenyl)ethylamine
is not subject to C&L (according to Regulation 1272/2008/EC and Directive 67/548/EEC).
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