Registration Dossier
Registration Dossier
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EC number: 415-430-8 | CAS number: 86403-32-9 CYASORB UV-3853 LIGHT STABILIZER; DASTIB 845; SANDUVOR 845
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 473 (1997)
- GLP compliance:
- yes
- Type of assay:
- other: in vitro mammalian cytogenicity (B10)
Test material
- Reference substance name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- EC Number:
- 415-430-8
- EC Name:
- A mixture of: 2,2,6,6-tetramethylpiperidin-4-yl-hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl-octadecanoate
- Cas Number:
- 86403-32-9
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-yl hexadecanoate; 2,2,6,6-tetramethylpiperidin-4-yl octadecanoate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mammalian cell line, other: Chin. Hamster, V79-Zellen
- Metabolic activation system:
- S9-Mix from rat liver
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 1...20 ug/ml
Concentration range in the main test (without metabolic activation): 1...20 ug/ml - Vehicle / solvent:
- MEM (Minimum Essential Medium), Biochrom, ohne FCS
- Details on test system and experimental conditions:
- Exposure period (with metabolic activation): 5 hours
Exposure period (without metabolic activation): 5 hours
with and without S9-Mix: 18h and 24h
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (>=6.25 ug/ml)
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (20 ug/ml)
- Additional information on results:
- No significant increase in the frequency of structural chromosomal aberrations was observed at any harvest time and concentration, either in the presence of aberrant cells.
No dose-dependent increase of poliploid cells was observed during evaluation of structural aberrations. - Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Genotoxicity is unknown.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
ambiguous without metabolic activation
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