Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Stability in organic solvents and identity of relevant degradation products

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline available
Principles of method if other than guideline:
1H-NMR spectra were recorded for testing stability and homogeneity of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in Solutol/ethanol/H2O/D2O at 2 different concentrations each.
GLP compliance:
not specified
Test substance stable:
yes
Transformation products:
no

Analytical Result:

Relative integrals of the aryl protons, 5 mg/mL in Solutol/ethanol/H2O/D2O 40/10/40/10

5 mg/mL  T0  2 h  4 d  Mean
Top of the vial  4.84  4.82  4.87  4.84
Middle of the vial  4.90  4.85  4.86  4.87
Bottom of the vial  4.81  4.83  4.90  4.85
Mean  4.85  4.83  4.88  4.85
RSD %  0.94  0.32  0.43  0.30

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (4.85) and multiplication with the prepared concentration of 5 mg/mL.

Concentration of the substance, 5 mg/mL in Solutol/ethanol/H2O/D2O 40/10/40/10

5 mg/mL   T0[mg/mL]  2 h [mg/mL]  4 d [mg/mL]
Top of the vial  4.997  4.977  5.028
Middle of the vial  5.059 5.008  5.018
Bottom of the vial  4.966  4.987  5.059
 Mean  5.008 4.990  5.035
 RSD % 0.94  0.32 0.43

Relative integrals of the aryl protons, 100 mg/mL in Solutol/ethanol/H2O/D2O 40/10/40/10

100 mg/mL  T0  2 h  4 d  Mean
Top of the vial  46.93  46.99  47.90  47.27
Middle of the vial  47.98  47.68  48.12  47.93
Bottom of the vial  47.94  48.11  47.51  47.85
Mean  47.62  47.59  47.84  47.68
RSD %  1.25  1.19  0.65  0.75

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (47.57) and multiplication with the prepared concentration of 100 mg/mL.

Concentration of the substance, 100 mg/mL in Solutol/ethanol/H2O/D2O 40/10/40/10

100 mg/mL  T0[mg/mL]  2 h [mg/mL  4 d [mg/mL]
Top of the vial 98.68  98.81  100.72
Middle of the vial  100.89  100.26  101.19
Bottom of the vial  100.81  101.17  101.19
 Mean  100.13  100.08  101.03
 RSD %  1.25  1.19  0.27
Conclusions:
Based on obtained results 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is considered to be stable and homogenous in Solutol/ethanol/H2O/D2O (40/10/40/10) at room temperature for at least 4 days.
Executive summary:

Two different concentrations (5 and 100mg/mL) of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in Solutol/ethanol/H2O/D2O (40/10/40/10) were prepared to observe the stability over time. The NMR quantification shows that 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is stable and homogenous at room temperature for at least 4 days.

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline available
Principles of method if other than guideline:
1H-NMR spectra were recorded for testing stability and homogeneity of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in acetone-d6/olive oil at 2 different concentrations each.
GLP compliance:
not specified
Test substance stable:
yes
Transformation products:
no

Analytical Result:

Relative integrals of the aryl protons, 10 mg/mL in acetone-d6/olive oil 4/1

10 mg/mL  T0  2 h  4 d  Mean
Top of the vial  109.75  109.70  109.57  109.67
Middle of the vial  109.14  109.17  108.58  108.96
Bottom of the vial  108.79  109.37  108.70  108.95
Mean  109.23  109.41  108.95  109.20
RSD %  0.44  0.24  0.50  0.38

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (109.27) and multiplication with the prepared concentration of 10 mg/mL.

Concentration of the substance, 10 mg/mL in acetone-d6/olive oil 4/1

10 mg/mL   T0[mg/mL]  2 h [mg/mL]  4 d [mg/mL]
Top of the vial  10.050  10.040  10.028
Middle of the vial  10.045 9.992   9.938
Bottom of the vial   9.957  10.010   9.949
 Mean  10.017 10.014   9.972
 RSD %  0.52  0.24  0.50

Relative integrals of the aryl protons, 500 mg/mL in acetone-d6/olive oil

500 mg/mL  T0  2 h  4 d  Mean
Top of the vial  1035.1  1024.2  1034.5  1031.3
Middle of the vial  1027.8  1028.0  1042.3  1032.7
Bottom of the vial  1025.0  1028.4  1041.0  1031.5
Mean  1029.3  1026.9  1039.3  1031.8
RSD %  0.51  0.23  0.40  0.08

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (1031.81) and multiplication with the prepared concentration of 500.5 mg/mL.

Concentration of the substance, 500 mg/mL in acetone-d6/olive oil

500 mg/mL  T0[mg/mL]  2 h [mg/mL  4 d [mg/mL]
Top of the vial  502.10  496.81  501.81
Middle of the vial  498.56  498.65  505.59
Bottom of the vial  497.20  498.85  504.96
 Mean  499.28  498.10  504.12
 RSD %  0.51  0.23  0.40
Conclusions:
Based on obtained results 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is considered to be stable and homogenous in acetone-d6/olive oil (4/1) at room temperature for at least 4 days.
Executive summary:

Two different concentrations (10 and 500mg/mL) of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in acetone-d6/olive oil (4/1) were prepared to observe the stability over time. The NMR quantification shows that 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is stable and homogenous at room temperature for at least 4 days.

Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
no guideline available
Principles of method if other than guideline:
1H-NMR spectra were recorded for testing stability and homogeneity of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in DMSO/DMSO-d6 at 2 different concentrations each.
GLP compliance:
not specified
Test substance stable:
yes
Transformation products:
no

Analytical Result:

Relative integrals of the aryl protons, 50 mg/mL in DMSO/DMSO-d6

50 mg/mL  T0  4 h  Mean
Top of the vial  89.47  89.56  89.52
Middle of the vial  89.74  89.50  89.62
Bottom of the vial  89.53  89.53  89.53
Mean  89.58  89.53  89.56
RSD %  0.16  0.03  0.063

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (89.56) and multiplication with the prepared concentration of 50 mg/mL.

Concentration of the substance, 50 mg/mL in DMSO/DMSO-d6

50 mg/mL  T0 [mg/mL]  4 h [mg/mL]
Top of the vial  49.95  50.00
Middle of the vial  50.10  49.97
Bottom of the vial  49.99  49.99
 Mean  50.01  49.99
 RSD %  0.16  0.03

Relative integrals of the aryl protons, 500 mg/mL in DMSO/DMSO-d6

500 mg/mL  T0  24 h  Mean
Top of the vial  179.55  182.46  181.01
Middle of the vial  182.01  177.69  179.85
Bottom of the vial  182.63  179.14  180.89
Mean  181.40  179.76  180.58
RSD %  0.90  1.36  0.35

Areas were turned into cocentrations by divsion of the individual integrals by the mean integral (180.58) and multiplication with the prepared concentration of 500 mg/mL.

Concentration of the substance, 500 mg/mL in DMSO/DMSO d6

500 mg/mL  T0[mg/mL]  4 h [mg/mL]
Top of the vial  497.2  505.2
Middle of the vial  504.0  492.0
Bottom of the vial  505.7  496.0
 Mean  502.29  497.76
 RSD %  0.90  1.36
Conclusions:
Based on obtained results 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is considered to be stable and homogenous in DMSO/DMSO-d6 (10/1) at room temperature for at least 24 hours.
Executive summary:

Two different concentrations (50 and 500mg/mL) of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' in DMSO/DMSO-d6 (10/1) were prepared to observe the stability over time. The NMR quantification shows that 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is stable and homogenous at room temperature for at least 24 hours.

Description of key information

'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' is considered to be stable and homogenous in DMSO/DMSO-d6 (10/1) for at least 24 hours, in acetone-d6/olive oil (4/1) and in Solutol/ethanol/H2O/D2O (40/10/40/10) for at least 4 days, respectively.

Additional information

Stability and homogeneity of 'Reaction mass of benzyl 2-ethylhexyl adipate and bis(2-ethylhexyl) adipate and dibenzyl adipate' at room temperature dissolved in different matrices at two concentrations were investigated. H-NMR spectra were used for quantification.