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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Section 173.240 (a) (1) and Appendix A
Principles of method if other than guideline:
One group of six (3 male and 3 female) albino rabbits weighing between 2.0 and 3.0 kg each was employed in this study. All animals had their back clipped free of hair 24 hours prior to testing. All of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied.
The following dosage level was administered: 1.0 mg/kg.
All rabbits were weighted and the correct amount of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal. The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. Gross autopsies were performed onall animals which died during the 14 day observation period and also on all survivors of the 14 day observation period.
GLP compliance:
no
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
2,5,8,11-tetramethyldodec-6-yne-5,8-diol
EC Number:
269-348-0
EC Name:
2,5,8,11-tetramethyldodec-6-yne-5,8-diol
Cas Number:
68227-33-8
Molecular formula:
C16H30O2
IUPAC Name:
2,5,8,11-tetramethyldodec-6-yne-5,8-diol
Constituent 2
Reference substance name:
2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
IUPAC Name:
2,5,8,11-tetramethyl-6-dodecyne-5,8-diol
Test material form:
other: white waxy solid

Test animals

Species:
rabbit
Strain:
other: albino
Sex:
male/female
Details on test animals or test system and environmental conditions:
3 males and 3 females

Administration / exposure

Type of coverage:
other: gauze patches for 24 hours
Vehicle:
other: none
Details on dermal exposure:
24 hours
Duration of exposure:
24 hours
Doses:
1.0 gr/kg bw
No. of animals per sex per dose:
3 male
3 female
Control animals:
no

Results and discussion

Preliminary study:
no prelimenary study
Effect levels
Sex:
male/female
Dose descriptor:
other: corrosion
Effect level:
> 1 mg/kg bw
Based on:
test mat.
Mortality:
none
Clinical signs:
other: very slight edema and erythema

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification