Registration Dossier
Registration Dossier
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EC number: 279-211-7 | CAS number: 79665-24-0
Endpoint summary
Administrative data
Description of key information
Additional information
Acute aquatic toxicity for two closely related structural analogues (CAS 40618-31-3 and CAS 52238-92-3) data on two trophic levels are available. This includes two studies on immobilization of the waterflea Daphnia magna (CAS 40618-31-3 and CAS 52238-92-3) and studies of toxicity on the green algae Desmodesmus subspicatus and Pseudokirchneriella supcapitata (CAS 68516-75-6 and CAS 71566-54-6).
Disazo condensation red pigments are all of low solubility in water and in octanol. They do not contain functional groups that are susceptible to pH dependent hydrolysis at environmentally relevant pH. The pigments are generally not readily biodegradable and additionally adsorption to the solid soil phase is not expected. Due to the low logPow and the high molecular weight of all pigments, bioaccumulation is not expected. Their relative density is between 1.4 and 1.61 and all decompose before melting at temperatures above 300°C. Since the molecular structure and the physico-chemical properties of the ‘red disazo condensation pigments’ are very similar, the available studies are sufficient to cover the aquatic toxicity endpoints of the whole group. Furthermore, studies on aquatic toxicity are available for the most water soluble pigment (CAS 71566-54-6) and the pigment with the highest logPow and highest octanol solubility (CAS 68516-75-6) to cover the complete range. Therefore, this read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as it is explained within the read across justification in chapter 13.
After exposure to analogues to Pigment Red 262, no effects on aquatic organisms occurred within the range of water solubility. These results confirm the expectation, that Pigment Red 262 is considered to be essentially not bioavailable, due to the large molecular size together with the negligible, low solubility.
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