Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 917-473-2 | CAS number: 188416-34-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The physical properties of the test substance particularly the high water solubility (HLS, 1996) and low partition coefficient (HLS, 1996) would suggest that if the substance was bioavailable it would be unlikely to pass into the central nervous system. Acute toxicology particularly the acute oral study (HLS), revealed systemic effects of the test substance in the form of clinical signs. Clear evidence of oral absorption was seen in both the acute and repeated dose studies. There was some limited evidence of absorption via the dermal route. In a 28 -day oral (gavage) study (HLS, 1998), rats were dosed with 15, 50 or 150 mg/kg/day. The 28 Day Oral Toxicity Study revealed extensive effects in the liver providing evidence of distribution and metabolism. The changes were seen in liver weight and at both macroscopic and microscopic examination, the extent of the effects followed a dosage related trend.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
