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EC number: 940-042-5
CAS number: 1254940-85-6
The acute oral toxicity of substance IFF TM 10-202 is greater than 2000 mg/kg bodyweight according to OECD Test Guideline 423 using the Acute Toxic Class Method.The acute dermal toxicity potential of the test material, IFF TM 10-202, gave an LD50 of > 2000 mg/kg body weight according to OECD Test Guideline 402, using a fixed dose method.
Dose Level mg/kg
Number of Animals Treated
Deaths During Day of Dosing(Hours)
Deaths During Period After Dosing(Days)
Individual Clinical Observations - 300 mg/kg
Animal Number and Sex
Effects Noted After Dosing(Hours)
Effects Noted During Period After Dosing(Days)
0= No signs of systemic
Individual Clinical Observations - 2000 mg/kg
0= No signs of systemic toxicity
P = Pilo-erection
H = Hunched posture
Pt = Ptosis
Rl = Labored
Rn = Noisy respiration
Rg =Gasping respiration
A = Ataxia
L = Lethargy
Individual Body Weights and Body Weight Changes -
Animal Numberand Sex
Body Weight (g) at Day
Body Weight Gain (g) During Week
Individual Body Weights and Body Weight Changes - 2000 mg/kg
Individual Necropsy Findings - 300 mg/kg
Time of Death
Killed Day 14
No abnormalities detected
Individual Necropsy Findings - 2000 mg/kg
The acute oral toxicity of substance IFF TM 10-202 is greater than 2000
mg/kg bodyweight according to OECD Test Guideline 423 using the Acute
Toxic Class Method.
Individual clinical observations and mortality data with dose level
at 2000 mg/kg
Animal No. & Sex
Effects noted after dosing (hours)
Effects noted during period after dosing
0 = No signs of systemic toxicity.
Individual dermal reactions - Males (Dose level 2000 mg/kg)
Animal No & Sex
0 = No reactions.
Individual dermal reactions - Females (Dose level 2000 mg/kg)
0 = No reactions D =
Slight desquamation Ss = Small superficial scattered scabs Cf = Crust
Individual body weights and body weight changes (Dose level
Body weight (g) at Day
Body Weight Change
The acute dermal toxicity potential of the test material, IFF TM 10-202,
gave an LD50 of > 2000 mg/kg body weight according to OECD Test
Guideline 402, using a fixed dose method.
The acute oral median lethal dose (LD50) of the test item in the female
Wistar strain rat was found to be greater than 2000 mg/kg body weight
(Globally Harmonized Classification System - Category 5, >2000 - 5000
mg/kg body weight; not toxic or harmful via the oral route, ≥
2000 mg/kg body weight according to Directive 67/548/EEC).
The acute dermal median
lethal dose (LD50)
of the test item in the Wistar strain rat was found to be greater than
2000 mg/kg body weight. The test item does not meet the criteria for
classification according to the Globally Harmonized System of
Classification and Labelling of Chemicals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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