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EC number: 940-042-5
CAS number: 1254940-85-6
The adsorption coefficient of substance TM 10-202 was determined to be be in the range 1.18 E+04 to 1.63 E+04, with a log10 Koc in the range 4.07 to 4.21 according to the OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge test using the HPLC method.
Quantification of the adsorption and desorption behaviour of the
test item to soils of differing pH, organic carbon content and textural
classification,using a batch equilibrium method was concluded not to be
feasible. Methods under consideration were OECD Method 106, 21st January
2000 and Method C18 Adsorption – Desorption using a Batch Equilibrium
Method, Commission Regulation (EC) No 440/2008 of 30 May 2008.
This conclusion was derived from low solubility of the test item
in water, such that the permitted working nominal concentration for the
investigation of behaviour in soils exceeded the lower recommended limit
for the methodology. As a result of the low solubility, it was also not
possible to satisfy the analytical method requirements of the method
guidelines. Further to this, partition coefficient data available for
the test item also exceeded the recommended domain for the methodology,
as the expected high percentage adsorption would result in insufficient
test item remaining in the aqueous phase for analysis.
In such an extreme case, the method
guidelines recommend the use of an alternative estimation method, such
as those based on available partition coefficient data and established
relationships between partition coefficient and adsorption coefficient,
and/or HPLC estimation methods. Since
issue of the above referenced batch equilibrium method guidelines, the
HPLC estimation method has been formalized within the guideline Method
121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Estimations of the adsorption coefficient were obtained by
calculation using Quantitative Structure Activity Relationships
(QSAR’s), the details of which are provided in the technical guidance
documents in support of Commission Directive 93/67/EEC on risk
assessment for new substances, and from the specialized predictive
software KOCWIN, version 2.00, September 2010, © 2000 to 2008, United
States Environmental Protection Agency. The results were an adsorption
coefficient (log10 Koc) range of 3.57 to 3.83.
Applying the HPLC estimation method to the test item, using a
procedure designed to be compatible with Method 121 of the OECD
Guidelines for Testing of Chemicals, 22 January 2001, resulted in an
adsorption coefficient (log10 Koc) range of
4.07 to 4.21.
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