Registration Dossier
Registration Dossier
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EC number: 201-873-2 | CAS number: 88-99-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. No doses defined.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the toxicity of polyvinylacetate phthalate in experimental animals
- Author:
- Schoneker D.R. et al.
- Year:
- 2 002
- Bibliographic source:
- Food and Chemical Toxicology 41 (2003) 405-413
Materials and methods
- Principles of method if other than guideline:
- male and female albino mice weighing 18-20 g, were used. The animals were fasted for a period of 4-16 h prior to treatment. Range-finding tests of the acute toxicity were conducted initially. 5% gum acacia was used as the vehicle. All surviving animals were maintained for a subsequent 14-day period. The LD50 was calculated from the mortality data.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phthalic acid
- EC Number:
- 201-873-2
- EC Name:
- Phthalic acid
- Cas Number:
- 88-99-3
- Molecular formula:
- C8H6O4
- IUPAC Name:
- benzene-1,2-dicarboxylic acid
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Breeder: Canadian Breeding Laboratories and Charles River Laboratories
weight at study initiation: 18-20g
fasting period: 4 to 16 hours prior to treatment
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 5% gum acacia
- Details on oral exposure:
- All surviving animals were maintained for a subsequent 14-day period. The LD50 was calculated from the mortality data according to Lichfield and Wilcoxan (1949).
- Doses:
- no data
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Phthalic acid, Mouse,LD50= >5000 mg/kg bw
Applicant's summary and conclusion
- Executive summary:
In an acute oral toxicity study in male and female albino mice the LD50 was >5000 mg/kg bw.
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