Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_environmental-fate-and-pathways.png)
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Episuite and the BCFBAF models are well documented and commonly used QSARs for predicting the bioaccumulation potential of chemicals. Constituents within LOA streams fall within the applicability domain of these models and they have been recommended by ECHA in the Information Requirement Guidelines.
- Reason / purpose for cross-reference:
- (Q)SAR model reporting (QMRF)
- Reason / purpose for cross-reference:
- assessment report
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Formerly called BCFWIN, the BCFBAF program estimates fish bioconcentration factor (BCF) and its logarithm using two different methods. The first is the traditional regression based on log KOW plus any applicable correction factors. The second is the Arnot-Gobas method, which calculates BCF from mechanistic first principles. BCFBAF also incorporates prediction of apparent metabolism half-life in fish, and estimates BCF and BAF for three trophic levels. The program is based on methodologies developed by Arnot-Gobas et al. (2003, 2006, 2008). A 5% lipid normalisation has been used for the Arnot-Gobas method BCF values, as recommended in OECD TG 305.
- Key result
- Type:
- BCF
- Value:
- >= 12 - <= 199 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: BCF Regression based estimation
- Remarks on result:
- other: Result from QSAR prediction. Range based on the measured constituents in this stream
- Key result
- Type:
- BCF
- Value:
- >= 1 - <= 167 L/kg
- Basis:
- whole body w.w.
- Calculation basis:
- other: BCF Arno-Gobas method (upper trophic) (5% lipid normalisation)
- Remarks on result:
- other: Result from QSAR prediction. Range based on the measured constituents in this stream
- Details on results:
- Of the 11 constituents, none have a BCF value of greater than 2000 L/kg ww. Details of the constituents and how their BCF predictions relate to the bioaccumulation assessment are found in the BCFBAF QMRF/QPRF and in the PBT report (see cross-reference).
- Conclusions:
- The predicted BCF values of the constituents of this substance range from 1 to 199 L/kg ww. Of the 11 constituents, none have a BCF value greater than 2000 L/kg ww.
- Executive summary:
The bioconcentration factor (BCF) values of the measured constituents of this substance (equal or above 0.1% w/w of the UVCB composition) have been predicted using the EPISUITE v4.11 BCFBAF (2017) model, which uses methodology descrived by Arnot-Gobas et al. (2003, 2006, 2008). The predicted BCF values range from 1 to 199 L/kg ww. Of the 11 constituents, none have a BCF value greater than 2000 L/kg ww.
Reference
Description of key information
A measured BCF is not available for any constituents in this substance. BCF have been predicted for these constituents. The predicted BCF values range from 1 to 199 L/kg ww. Of the eleven constituents, none have a BCF value greater than 2000 L/kg ww. Since these values correspond to QSAR predictions for individual constituents, a key value that is representative for the substance cannot be provided.
Key value for chemical safety assessment
Additional information
The bioconcentration factor (BCF) has been predicted using the EPISUITE v4.11 BCFBAF (2017) model, which uses methodology described by Arnot-Gobas et al. (2003, 2006, 2008). The predicted BCF values range from 1 to 199 L/kg ww. Of the eleven constituents, none have a BCF value of greater than 2000 L/kg ww.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)