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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 16 April 2021 to 14 May 2021
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- July 17, 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Batch/Lot number: 381890
Purity: 99.8% - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Secondary effluent, microorganisms from a domestic wastewater treatment plant. The secondary effluent was supplied from one of the sewage plant for domestic sewage in Veszprém county, Hungary.
- Preparation of inoculum for exposure: After collection of a fresh sample of secondary effluent could settle for approximately one hour, then the decanted effluent or filtrate was aerated until use. - Duration of test (contact time):
- 28 h
- Initial conc.:
- 4.4 mg/L
- Based on:
- test mat.
- Details on study design:
- TEST CONDITIONS
- Composition of medium:
a) Solution: KH2PO4 2.125 g
K2HPO4 5.4375 g
Na2HPO4 x 12H2O 16.795 g
NH4Cl 0.125 g
Deionised water ad 250 mL
b) Solution: MgSO4 x 7 H2O 5.625 g
Deionised water ad 250 mL
c) Solution: CaCl2 x 2 H2O 9.10 g
Deionised water ad 250 mL
d) Solution: FeCl3 x 6 H2O 0.25 g
Deionised water ad 1000 mL
- Test temperature: 22 oC
- pH: 7.46
- Aeration of dilution water: yes
TEST SYSTEM
- Culturing apparatus: BOD bottles (300 mL) with special neck and glass stoppers.
- Number of culture flasks/concentration: at least 10 bottles
- Measuring equipment: The COD (chemical oxygen demand) of the test item was determined in the analytical department of the test facility using Lovibond® COD Measuring System. The oxygen concentrations were measured with an oxygen meter with a stirring O2 electrode.
- Test performed in closed vessels: yes
SAMPLING
- Sampling frequency: Oxygen measurements were performed in duplicate on days 0, 7, 14, 21 and 28.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Only filtered inoculum was added to 3.38 litres of aqueous test medium.
- Toxicity control: The Test Item (340.0 mL) and the reference item stock solutions (34.0 mL) were mixed into 3.40 litres of aqueous test medium corresponding to 4.4 mg/L test item (ThOD of 5.940 mg O2/L) and 3.6 mg/L reference item (ThOD of 6.012 mg O2/L). - Reference substance:
- benzoic acid, sodium salt
- Preliminary study:
- A 14-day preliminary test was conducted to determine the approximate biodegradation of the test item. It showed 6.7% biodegradation after 14 days of exposure.
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Under the test conditions the percentage biodegradation of Test Item reached a mean of 0.0 % after 28 days based on the COD of the test item. According to the test guidelines the pass level for ready biodegradability is removal of 60 % COD/ThOD. Therefore, the test item is considered not readily biodegradable.
- Key result
- Parameter:
- COD
- Value:
- 0 mg O2/g test mat.
- Results with reference substance:
- The reference item Sodium benzoate was sufficiently degraded to a mean of 75.8 % after 14 days,
and to a mean of 91.7 % after 28 days of incubation, based on ThOD, thus confirming the suitability
of the used inoculum. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Under the test conditions the percentage biodegradation of Test Item reached a mean of 0.0 % after 28 days based on the COD of the test item. The test item is considered not readily biodegradable.
- Executive summary:
The test item was investigated for its ready biodegradability in a Closed Bottle Test over a period of 28 days, according to OECD Guideline 301 D under GLP.
Under the test conditions the percentage biodegradation of Test Item reached a mean of 0.0 % after 28 days based on the COD of the test item. According to the test guidelines the pass level for ready biodegradability is removal of 60 % COD/ThOD. Therefore, the test item is considered not readily biodegradable.
Reference
Description of key information
Under the test conditions the percentage biodegradation of Test Item reached a mean of 0.0 % after 28 days based on the COD of the test item. The test item is considered not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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