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EC number: 826-544-6 | CAS number: 29118-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 = approx 1242 mg/kg bw (QSAR)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Model developer(s) and contact details:
U.S. Environmental Protection Agency
Reference(s) to main scientific papers and/or software package
Martin, T; Toxicity Estimation Software Tool (TEST); U.S. Environmental Protection Agency, Washington, DC, (2016)
https://www.epa.gov/chemical-research/toxicity-estimation-software-tool-test
Availability of information about the model:
Freely available through the EPA web site:
https://www.epa.gov/chemical-research/toxicity-estimation-software-tool-test
Endpoint:
Endpoint represents the amount of the chemical (mass of the chemical per body weight of the rat) which when orally ingested kills half of rats - Specific details on test material used for the study:
- C(=C\F)\C(F)(F)F
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 240 mg/kg bw
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- A LD50 (-log(LD50 mol/kg) of 2.0 (i.e. about 1240 mg/kg) can be considered a good precautionary estimation of oral rat toxicity for the target in the T.E.S.T. Oral rat LD50 v 4.2.1 model.
- Executive summary:
Predicted LD50 as mg/kg is 1272 mg/kg. The results of the model can’t be considered reliable in terms of numerical value because it is likely that the model overestimate the toxicity. Despite the low reliability of the prediction, this estimation can be used in a conservative way. Closest neighbors in the training set (151-67-7 and 6186-91-0) over-predicted (with an error in prediction higher than 1 log unit) and the MAE of similar compounds in the training set higher than the error observed for the whole dataset. Indeed, because highly similar compounds identified in the dataset are over-predicted, the model is also likely to predict the target as more toxic than its real value. A LD50 (-log(LD50 mol/kg) of 2.0 (i.e. about 1240 mg/kg) can be considered a good precautionary estimation of oral rat toxicity for the target.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 242 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
One QSAR model was available (T.E.S.T. Oral rat LD50 v. 4.2.1) and was used to predict acute oral toxicity. The predicted LD50 as mg/kg is 1272 mg/kg. The results of the model can’t be considered reliable in terms of numerical value because it is likely that the model overestimate the toxicity. Despite the low reliability of the prediction this estimation can be used in a conservative way. Closest neighbors in the training set (151-67-7 and 6186-91-0) over-predicted (with an error in prediction higher than 1 log unit) and the MAE of similar compounds in the training set higher than the error observed for the whole dataset. Indeed, because highly similar compounds identified in the dataset are over-predicted, the model is also likely to predict the target as more toxic than its real value. A LD50 (-log(LD50 mol/kg) of 2.0 (i.e. about 1240 mg/kg) can be considered a good precautionary estimation of oral rat toxicity for the target.
Justification for classification or non-classification
Based on the available information in the dossier, the substance (1Z)-1,3,3,3-Tetrafluoroprop-1-ene (CAS No. 29118-25-0) is classified for acute oral toxicity (Category 4), when the criteria outlined in Annex I of 1272/2008/EC are applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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