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Diss Factsheets
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EC number: 946-378-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study completion date: 17 April, 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Test substance: FAT 31064/F
Solubility: 50 g/L (insoluble in water)
Storage: Room temperature
Appearance: Solid - Vehicle:
- no
- Details on test solutions:
- 1, 3.2, 10, 32 and 100 mg/L
- Test organisms (species):
- anaerobic bacteria
- Details on inoculum:
- Test organism mixed culture of bacteria (sludge of a Husman apparatus)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Study terminated after 3 h
- Test temperature:
- 20.5 °C
- Nominal and measured concentrations:
- 1, 3.2, 10, 32 and 100 mg/L
- Details on test conditions:
- Temperature: 20.5 °C
Estimation technique: O2-consumption, measured with an oxygen-sensitive electrode system: OXI DIGI 550. - Reference substance (positive control):
- yes
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- The % inhibitions observed were 0.0, 4.0, 0.0, 4.5 and 15.7 % at concentrations of 1, 3.2, 10, 32 and 100 mg/L, respectively.
- Results with reference substance (positive control):
- The IC50 of the reference substance 3,5-Dichlorophenol is: 15 mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- The IC50 (3 h) of FAT-31064/F was found to be greater than 100 mg/L
- Executive summary:
A toxicity study of FAT 31064/F to activated sludge was determined in a 3-hours respiration inhibition test according to OECD test guideline 209 following GLP. The test substance concentrations tested were 1, 3.2, 10, 32 and 100 mg/L.
The estimation technique used was O2 consumption measured with oxygen sensitive electrode system. The reference substance used was 3,5 -Dichlorophenol. The % inhibitions observed were 0.0, 4.0, 0.0, 4.5 and 15.7 % at concentrations of 1, 3.2, 10, 32 and 100 mg/L, respectively. Thus, the IC50 (3 h) of FAT-31064/F was found to be greater than 100 mg/L The IC50 (3h) of 3,5 -Dichlorophenol was found to be 15 mg/L.
Reference
Description of key information
In the key study, the toxicity of FAT 31064/F to activated sludge was determined in a 3-hours respiration inhibition test according to OECD test guideline 209 following GLP. The test substance concentrations tested were 1, 3.2, 10, 32 and 100 mg/L. The estimation technique used was O2 consumption measured with oxygen sensitive electrode system. The reference substance used was 3,5 -Dichlorophenol.The % inhibitions observed were 0.0, 4.0, 0.0, 4.5 and 15.7 % at concentrations of 1, 3.2, 10, 32 and 100 mg/L, respectively. Thus, the IC50 (3 h) of FAT-31064/F was found to be greater than 100 mg/L The IC50 (3h) of 3,5 -Dichlorophenol was found to be 15 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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