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EC number: 812-681-9 | CAS number: 1215310-75-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 2016 - Feb 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methanesulfonyl-2-(trifluoromethyl)benzaldehyde
- EC Number:
- 812-681-9
- Cas Number:
- 1215310-75-0
- Molecular formula:
- C9H7F3O3S
- IUPAC Name:
- 4-methanesulfonyl-2-(trifluoromethyl)benzaldehyde
- Test material form:
- solid: particulate/powder
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- After the 3-hour contact time, the oxygen consumption was
recorded for a period of approximately 10 minutes. During
measurement, the sample was not aerated but continuously
stirred on a magnetic stirrer.
The pH was determined in the remaining part of the reaction
mixture. This procedure was repeated for all test/reference item
concentrations and blank controls.
The medium temperature was recorded continuously in a
temperature control vessel(s). The temperature control vessel(s)
was/were identically prepared compared to the blank control
vessels. A temperature control vessel with a REES sensor was
placed in each fume cupboard of the climate room.
Oxygen recording Determination of oxygen was performed with multiple oxygen
probes connected to a BlueBox (GO-Systemelektronik GmbH,
Germany), a multichannel measuring and controlling system.
Test solutions
- Vehicle:
- yes
- Remarks:
- Milli-RO water
- Details on test solutions:
- The batch of QAW039-C2 tested was a yellowish powder with a purity of 99.7%. No
correction was made for the purity/composition of the test item.
The test item was not sufficiently soluble to allow the preparation of a 10 g/L stock solution
in water. Therefore, 1 litre test bottles were filled with 200 mL of test item mixtures in Milli-
RO water (tap water purified by reverse osmosis; Millipore Corp., Bedford, Mass., USA)
with initial loading rates of 2.5 times the final loading rate. These mixtures were stirred in
closed dark brown bottles for approximately 24 hours. Subsequently, 16 mL synthetic
medium made up to 50 mL with Milli-RO water and 250 mL sludge were added resulting in
the required loading rates. Optimal contact between the test item and
test organisms was ensured applying continuous aeration and stirring.
In a combined limit/range-finding test loading rates of 10, 100 and 1000 mg/L were tested.
The highest loading rate was tested in triplicate, lower loading rates consisted of one
replicate. In addition, a blank control (6 replicates) and an abiotic control (1 replicate) were
tested.
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- The sludge was coarsely sieved (1 mm) and allowed to settle. The supernatant was removed and ISO-medium was added. A small amount of the sludge was weighed and dried overnight at ca. 105°C to determine the amount of suspended solids (3.0 g/L of sludge, as used for the test). The batch of sludge was used one day after collection; therefore 50 mL of synthetic medium (=sewage feed) was added per litre of activated sludge at the
end of the collection day. The sludge was kept aerated at test temperature until use. The pH was 5.9 on the day of testing.
The sludge was buffered to a pH of 7.1 using a 70 g/L sodium bicarbonate solution. Before the sludge was used the respiration
rate of the sludge was determined to verify the quality of the sludge. The respiration rate was in agreement with the validity criteria.
Adjusted ISO-medium, formulated using RO-water (tap water purified by reverse osmosis; GEON Waterbehandeling, Berkel-
Enschot, The Netherlands) with the following composition:
CaCl2.2H2O 211.5 mg/L
MgSO4.7H2O 88.8 mg/L
NaHCO3 46.7 mg/L
KCl 4.2 mg/L
Study design
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20 and 22°C
- pH:
- 7.1 and 8.1
- Nominal and measured concentrations:
- The combined limit/range-finding test showed 8, 8 and an average of 44% inhibition of the respiration rate at a loading rate of 10, 100 and 1000 mg/L, respectively. The inhibition observed at 1000 mg/L was statistically significant; the EC50 was determined to be higher than 1000 mg/L. There was no significant oxygen uptake from abiotic processes.
- Details on test conditions:
- Contact time 3 hours, during which aeration and stirring took place.
Vessels All glass open bottles/vessels.
Milli-RO water Tap water purified by reverse osmosis (Millipore Corp., Bedford, Mass., USA).
Synthetic medium 16 g peptone
(=sewage feed) 11 g meat extract
3 g urea
0.7 g NaCl
0.4 g CaCl2.2H2O
0.2 g MgSO4.7H2O
2.8 g K2HPO4
Dissolved in Milli-RO water, made up to 1 litre and filtered. The pH was within 7.5 ± 0.5.
Air supply Clean, oil-free air.
Aeration The aeration was adjusted in such a way that the dissolved oxygen concentration at the start was above 60-70% saturation
(60% of air saturation is > 5 mg/L at 20°C) and to maintain the sludge flocs in suspension. - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrations
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this present test the EC50 of QAW039-C2 was determined to be above 1000 mg/L.
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