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2,6-bis({[bis(2-hydroxyethyl)amino]methyl})-4-[2-(3-{[bis(2-hydroxyethyl)amino]methyl}-4-hydroxyphenyl)propan-2-yl]phenol; 2,6-bis({[bis(2-hydroxyethyl)amino]methyl})-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; 2-[(2-hydroxyethyl)amino]ethan-1-ol; 2-{[bis(2-hydroxyethyl)amino]methyl}-4-[2-(3-{[bis(2-hydroxyethyl)amino]methyl}-4-hydroxyphenyl)propan-2-yl]phenol; 2-{[bis(2-hydroxyethyl)amino]methyl}-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
EC number: 943-503-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Diethanolamine and Bisphenol A are stable at pH 4, 7, 9. At 25 °C the following DT50 values resulted:
pH 7: 1935 h (Mannich Base 1) and 976 h (Mannich Base 2)
pH 9: 238.1 h (Mannich Base 1) and 117.9 h (Mannich Base 2)
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 117.9 h
- at the temperature of:
- 25 °C
Additional information
One experimental study according to OECD 111 is available
investigating the abiotic hydrolysis of the test substance (GLP;
Neuland, 2015). Diethanolamine is known to be stable in aqueous
solutions. Thus, the study was focused on the hydrolysis of the
remaining constituents Bisphenol A, Mannich Base 1 and Mannich Base 2.
A preliminary study was performed at pH 4, 7 and 9 at 50 °C for 5 d. As
a result, the components Bisphenol A, Mannich Base 1 and Mannich Base 2
are considered to be stable at pH 4 at 50 °C. Thus, it can be assumed
that the constituents are also stable at 25 °C.
The main test was performed at 25 °C with Mannich Base 1 and Mannich
Base 2 at pH 7 and 9 for 32 d (hydrolysis was < 90 %). DT50 values of
1935 h (Mannich Base 1, pH 7), 238.1 h (Mannich Base 1, pH 9), 976 h
(Mannich Base 2, pH 7) and 117.9 h (Mannich Base 2, pH 9) were
calculated. The hydrolysis products of Mannich Base 1 and Mannich Base 2
were analysed by HPLC-UV/LC-MS.
2-(Hydroxymethyl)-4-[1-(p-hydroxyphenyl)-1-methylethyl]phenol is the
transformation product of Mannich Base 1 at pH 7 and 9.
4-{1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-1-methylethyl}-2-(hydroxymethyl)phenol
is the transformation product from Mannich Base 2 at pH 7 and 9.
Diethanolamine is the third transformation product from hydrolysis.
In conclusion, hydrolysis is not a significant degradation process in
the environment.
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