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EC number: 943-438-6 | CAS number: 90063-59-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 July 1990 - 24 August 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- the results of this key study are compiled in a summary report only representing the most crucial results, lacking information on the blanks and reference substance. Raw data should be available.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- yes
- Remarks:
- - ferric chloride stock solution was 0.25g not 0.2g. The slight difference in composition of the mineral salts medium was trusted to have no effect on the results.
- Principles of method if other than guideline:
- The study was conducted in accordance to draft Ecotoxicology SOP 158 01. However, the EDTA stock solution contained 0.4g (as recommended in the 1988 OECD Ring Test) and not 0.5g as advised by the draft SOP 158 01.
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Secondary effluent from an unacclimatised activated sludge plant
- Details on inoculum:
- - Source of inoculum/activated sludge: Secondary effluent from an unacclimatised activated sludge plant at URL North
- Preparation of inoculum for exposure: 10% by volume of activated sludge plant secondary effluent was filtered through Whatman filter paper (541) to remove coarse particulate matter.
- Pretreatment: The level of dissolved inorganic carbon (DIC) was reduced by sparging the filtered effluent with nitrogen after prior adjustment of the pH to 6.5. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 9.4 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral salts medium (as recommended in the 1988 OECD Ring test)
- Test temperature: Air temperature 18-21°C; Temperature in the liquid medium 21.5-23°C
- pH: 6.5
- pH adjusted: yes
- Other: EDTA stock solution (for the preparation of the mineral salts medium) contained 0.4g instead of 0.5g as recommended in the draft Ecotoxicology SOP 158 01; Nominal Carbon added to medium: 940 µg (assuming 100% purity of compound)
TEST SYSTEM
- Culturing apparatus: 160mL vessels (hypovials) containing 100mL mineral salts medium inoculated with secondary effluent and the respective test of reference substance
- Method used to create aerobic conditions: headspace of vessels filled with air (60mL), containing approx. 6 times the mass of oxygen required for the complete oxidation of the substance.
- Measuring equipment: Ionics 555 Inorganic Carbon Analyser for measurement of CO2/DIC (headspace gas and liquid medium)
- Test performed in closed vessels due to significant volatility of test substance: yes
SAMPLING
- Sampling frequency: Day 4, 7, 11, 14, 18, 21, 25 and 28
- Sampling method: At each interval a vessel is removed and the carbon dioxide concentration of the headspace gas determined. The seal of the vessel is then broken and the concentration of inorganic carbon in the test medium measured.
CONTROL AND BLANK SYSTEM
There are no reference substance and blank controls included in the report, however the report contains relevant summary data for 10 fragrance ingredients, including Litsea cubeba. The test was part of a screening of a range of fragrances of the same functional chemistry. - Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 103.9
- Sampling time:
- 28 d
- Remarks on result:
- other: Given the allowed error in biodegradation studies of ±20% it is regarded as applicable to interpret the 103.9% for Litsea cubeba as 100% biodegradation.
- Validity criteria fulfilled:
- not specified
- Remarks:
- no information on difference between replicates and CO2 evolution in blank, toxicity control not applicable as substance was found to be readily biodegradable.
- Interpretation of results:
- readily biodegradable
- Conclusions:
- As part of a screening test of a range of same functional chemicals, Litsea cubeba essential oil can be regarded as readily and ultimately biodegradable, with a relatively high percentage biodegradation in comparison to other substances tested.
- Executive summary:
The performed sealed vessel test is a CO2 production test according to OECD Guideline 301B. The test was suitable to determine the ready and ultimate biodegradability of Litsea cubeba essential oil. Unilever Research compiled a summary report presenting the ready biodegradability results of the substance Litsea cubeba essential oil within a group of 10 other substances, all possessing a similar chemical functionality and thus resulting in the omission of a reference substance and blank controls during the test performance.
A biodegradation rate of nearly 104% on day 28 for Litsea cubeba essential oil results in a classification as readily biodegradable.
Reference
Description of key information
The performed sealed vessel test is a CO2 production test according to OECD Guideline 301B. The test was suitable to determine the ready and ultimate biodegradability of Litsea cubeba essential oil. Unilever Research compiled a summary report presenting the ready biodegradability results of the substance Litsea cubeba essential oil within a group of 10 other substances, all possessing a similar chemical functionality and thus resulting in the omission of a reference substance and blank controls during the test performance. A biodegradation rate of nearly 104% on day 28 for Litsea cubeba essential oil results in a classification as readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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