Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015.3.27-2015.5.13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 1.24
- Temp.:
- 20 °C
- Remarks on result:
- other: pH data was not available
- Details on results:
- Recoveries of Red 620 in octanol phase and water phase were 85.3±3.1%, 83.3±1.3%, respectively and the Relative Standard Deviation (RSD) was less than 20% (Table 1, 2).
LogPow values of Red 620 from the all three runs with the different solvents ratios were 1.28±0.01 (2 mL, test 1), 1.15±0.04 (4 mL, test 2), 1.29±0.00 (1 mL, test 3). The average value of LogPow is 1.24 ± 0.08 (Table 3, Fig 1).
Applicant's summary and conclusion
- Conclusions:
- The average logPow value from the all three runs with the different solvents ratios was 1.24± 0.08. The variation of partition coefficient calculated with different volume ratio was within ±0.3 logPow. This result was acceptable range specified by the National Institute of Environmental Research, Korea and OECD test guidelines.
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