1-Butanone, 1-[3-(hydroxymethyl)-1-piperidinyl]-3-methyl-

Guidance on Safe Use

First-aid measures

General information - Immediately remove any clothing soiled by the product. Do not leave affected persons unattended.

Skin exposure - Remove contaminated clothes. Wash skin with large volumes of water (or soap and water). If irritation persists, or any sign of tissue damage is apparent, obtain medical advice immediately.

Eye exposure - Irrigate copiously with water for at least 10 minutes. Then consult a doctor.

Accidental ingestion - Obtain medical advice immediately. Rinse mouth with water. Give up to one tumbler (half pint) of milk or water.

Excessive inhalation - Remove the individual to fresh air and keep at rest. Obtain medical advice immediately.

General comments - As in all cases of potential poisoning, supportive therapy is of the utmost importance.

Fire-fighting measures

Suitable extinguishing agents - Use fire extinguishing methods suitable to surrounding conditions.

· For safety reasons unsuitable extinguishing agents - Water with full jet

· Special hazards caused by the substance, its products of combustion or resulting gases - Nitrogen oxides (NOx)

· Protective equipment - Wear self-contained respiratory protective device. Do not inhale explosion gases or combustion gases.

· Additional information - Cool endangered receptacles with water spray.

Accidental release measures

Personal precautions - Keep unprotected persons away. Wear protective equipment. Gloves (natural rubber if possible) should be worn when handling spillages. Half-mask should be worn when handling spillages. No smoking. Avoid naked flames or other potential sources of ignition (eg. electrical equipment). Avoid skin contamination and inhalation of vapour. Good personal washing routines should be followed after accidental releases.

Ensure adequate ventilation in working areas foliowing accidental releases.

Environmental precautions - Do not discharge directly into drains, into soil or into the aquatic environment. Inform respective authorities in case of seepage into water course or sewage system. Do not allow to enter sewers/ surface or ground water.

Methods for cleaning up - Pick up mechanically. Dispose of the material collected according to regulations.

Additional information: No dangerous substances are released.

Handling and storage

Handling - Prevent formation of dust. Open and handle receptacle with care. Ensure good ventilation/exhaustion at the workplace. Do not dry clean dust covered objects and floors. Wash thoroughly with plenty of water.

Information about fire and explosion protection - Protect against electrostatic charges. Emergency cooling must be available in case of nearby fire.

Storage - Requirements to be met by storerooms and receptacles: No special requirements.

· Information about storage in one common storage facility: Not required.

· Further information about storage conditions: Store in cool, dry conditions in well sealed receptacles.

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipement controls in accordance with risk-based management system is available at each manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Processor/User of the Registrant's intermediate.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

not regulated

Shipping information

Proper shipping name and description:

HYDROXYVALERAMIDE

Chemical name:

(+)-1-[(3S)-3-(HYDROXYMETHYL)-1-PIPERIDINYL]-3-METHYL-1-BUTANONE

Language:

English

Labels:

not classified under CLP and DSD

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

not regulated

Shipping information

Proper shipping name and description:

HYDROXYVALERAMIDE

Chemical name:

(+)-1-[(3S)-3-(HYDROXYMETHYL)-1-PIPERIDINYL]-3-METHYL-1-BUTANONE

Language:

English

Labels:

not classified under CLP and DSD

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

not regulated

Shipping information

Proper shipping name and description:

HYDROXYVALERAMIDE

Chemical name:

(+)-1-[(3S)-3-(HYDROXYMETHYL)-1-PIPERIDINYL]-3-METHYL-1-BUTANONE

Labels:

-

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

not regulated

Shipping information

Proper shipping name and description:

HYDROXYVALERAMIDE

Chemical name:

(+)-1-[(3S)-3-(HYDROXYMETHYL)-1-PIPERIDINYL]-3-METHYL-1-BUTANONE

Labels:

-

Remarks

SpecialProvisions

Exposure controls / personal protection

- Exposure controls - Do not subject to unnecessarily high temperature during processing. Maintain adequate ventilation in working areas.

General protective and hygienic measures:

The usual precautionary measures are to be adhered to when handling chemicals.

Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Avoid contact with the eyes and skin.

  - Respiratory protection: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use self-contained respiratory protective device.

  - Hand protection: The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.

Due to missing tests no recommendation to the glove material can be given for the product/ the preparation/the chemical mixture.

Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation

· Material of gloves - The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.

· Penetration time of glove material: The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.

· Eye protection: Safety glasses

· Body protection: Protective work clothing

Stability and reactivity

Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.

· Materials to be avoided:

· Dangerous reactions No dangerous reactions known.

· Dangerous decomposition products: No dangerous decomposition products known.

Disposal considerations

Residual quantities of the product should be treated according to the instructions given under points 6, 7 and 8 of the SDS. Wastes should be eliminated according to national or regional regulatory requirements currently in force.

The generation of hazardous wastes in terms of quantity and hazardousness should be minimized, by disposing them as close to the source of generation as possible, thus reducing the movement of hazardous wastes.

For the disposal of wastes and packaging material, the services of a licensed waste management company is advised, with recycler, reclaimer, landfill, incinerator or other thermal destruction devices.