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EC number: 695-988-9 | CAS number: 100556-82-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is practically non-toxic.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- May to July 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions; the tested substance is a precursor or Reactive Black 5 Bis-Vinyl and hydrolyses in aqueous solution from the bis-ester to the bis-vinyl form
- Principles of method if other than guideline:
- Internal Guideline Hoechst AG
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: mixed-race albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own breeding facility
- Weight at study initiation: 80 to 128 g
- Fasting period before study: 12 hours prior administration
- Housing: 10/cage
- Diet: Altromin rat standard diet ad libitum
- Water: tap ad libitum
- Acclimation period: -
IN-LIFE DATES: From: 01. Jun. 1965 To: 25. Jun. 1965 - Route of administration:
- oral: gavage
- Vehicle:
- other: 2% starch
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
- Amount of vehicle (if gavage): 40, 50, and 60 mL/kg bw
- Justification for choice of vehicle: provide homogeneous suspension
- Doses:
- 10, 12.5, 15 g/kg body weight
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Details on study design:
- Weight range at start: 80 to 128 g
Test substance concentration: 25%
Withhold of food 12 hours prior to test substance administration
Observation period: 7 days after test substance administration - Statistics:
- Determination of LD50: graphical in probability grid
- Preliminary study:
- 3.2 and 10 g/kg in 3 female rats/dose group.
No deaths occurred.
Clinical signs: diarrhea, test compound in feces - Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 14 000 - < 14 500 mg/kg bw
- Mortality:
- no deaths at 10000 and 12500 mg/kg. 9/10 rats at 15000 mg/kg died; seven rats within 24 hours, one on Day 9 and one on Day 12.
- Clinical signs:
- other: 10000 mg/kg: NAD 12500 mg/kg: diarrhea, prone position and ataxia in some animals 15000 mg/kg: diarrhea, test compound in feces
- Gross pathology:
- no data
- Other findings:
- no data
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Spector - Handbook of Toxicology
- Conclusions:
- LD50 above 5000 mg/kg bw.
No classification required.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 14 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Due to the physico-chemical properties of the test item, dermal penetration is most unlikely. Due to the good water solubility, the toxicologically most relevant route of exposure is the oral one. Single dose studies with oral gavage of Reactive Black 5 at doses up to 15000 mg/kg body weight are available. These studies showed that Reactive Black 5 has a very low toxicity with an oral LD50 between 14000 and 14500 mg/kg body weight. It is therefore scientifically not justified to perform an additional acute toxicity study with dermal application for Reactive Black 5 bis-vinyl.
Inhalative exposure of workers to Reactive Black 5 bis-vinyl is very unlikely, as production and spray drying is done in a closed process without isolation of reaction products. The isolated product are dust free granules or dedusted powders (non-dusty solid) therefore inhalative exposure of down-stream users is very unlikely, too.
Justification for classification or non-classification
Based on the above stated assessment of the acute oral toxicity the substance does not need to be classified for Acute Oral toxicity according to GLP (Regulation (EC) No 1272/2008 of The European Parliament and of The Council) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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