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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 939-726-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, guideline study, published in peer reviewed literature, fully adequate for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Modeling acute and chronic toxicity of nonpolar narcotic chemicals and mixtures to Ceriodaphnia dubia.
- Author:
- Niederlehner BR, Cairns J, Smith EP
- Year:
- 1 998
- Bibliographic source:
- Ecotoxicol. Environ. Saf. 39, 136-146.
Materials and methods
Test guideline
- Guideline:
- other: US EPA 600/4-91-003
- Principles of method if other than guideline:
- Modification to minimise volatilisation. Instead of 30ml beakers, individual organisms were tested in 25ml borosilicate glass vials, filled to capacity and closed tightly with teflon PTFE-line silicon septa held in place with poplyproplyene screw on caps.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Toxicant concentrations were monitored at the start and end of the experiment. Newly prepared test solution and 24hours old test solution were analysed.
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- Obtained from Aquastar Inc (Mobile, Alabama) and cultured in house.
Study design
- Test type:
- other: daily renewal
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Post exposure observation period:
- none
Test conditions
- Hardness:
- Mean 68.3 mg/L
- Test temperature:
- data not reported
- pH:
- Mean 7.598
- Dissolved oxygen:
- > 7 ppm
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal 3, 5, 8, 30, 45uM. Acute results reported as the geometric mean of the measured starting concentrations. Replicates that lost >50 % test substance between renewals were excluded (no info on whether this rule was applied).
- Details on test conditions:
- Photoperiod 16L:8D. Daphnids fed a mixture of algal cells and ceral leaf at 3E5 algal cells.ml/L and <0.03mg.ml/L cereal solids.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 2 d
- Dose descriptor:
- LC50
- Effect conc.:
- 3.78 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- Only the highest test concentration resulted in mortality, with 60% mortality after 48 hours. 2 day LC50 equals 3.78mg/L.
- Reported statistics and error estimates:
- 99.8 % confidence intervals 29-> 45uM
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48 hour EC50 for acute toxicity to aquatic invertebrates is 3.78 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.