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EC number: 654-333-7 | CAS number: 5471-90-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
/ - Radiolabelling:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 100 mg/L in the three buffer solutions. Due to the solutions being hazy, the solutions were then filtered through 0.2 μm Nylon membrane filters. After filtration, the solutions were observed to be free from undissolved material. The test solutions were split into individual vessels for each data point. The solutions were shielded from light whilst maintained at the test temperature. An aliquot of each sample was diluted by a factor of two using methanol.
- Buffers:
- buffer solution
pH 4:
Citric acid: 0.06 mol dm-3
Sodium chloride: 0.04 mol dm-3
Sodium hydroxide: : 0.07 mol dm-3
pH7
Disodium hydrogen orthophosphate (anhydrous): 0.03 mol dm-3
Potassium dihydrogen orthophosphate: 0.02 mol dm-3
Sodium chloride: 0.02 mol dm-3
pH9
Disodium tetraborate: 0.01 mol dm-3
Sodium chloride: 0.02 mol dm-3
These solutions were subjected to ultrasonication and degassing with nitrogen to minimize dissolved oxygen content. - Estimation method (if used):
- /
- Details on test conditions:
- Tier 1
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of at least 288 hours. Due to issues with some of the standard solutions/test results, the Preliminary Test/Tier 1 was then repeated.
Tier 2
Results from the Preliminary Test/Tier 1 showed it was necessary to undertake further testing at pH 9, with solutions being maintained at 60.0 ± 0.5 °C and 70.0 ± 0.5 °C.
The concentration of the sample solution was determined by high performance liquid chromatography (HPLC).
Standards
Duplicate standard solutions of test item were prepared in methanol: relevant buffer solution (50:50 v/v) at a nominal concentration of 50 mg/L.
Duplicate standard solutions of test item were prepared in methanol: purified water (50:50 v/v) at a nominal concentration of 50 mg/L (Tier 2 only) - Duration:
- 288 h
- pH:
- 9
- Duration:
- 288 h
- pH:
- 7
- Temp.:
- 50
- Duration:
- 288 h
- pH:
- 4
- Temp.:
- 50
- Number of replicates:
- 1
- Negative controls:
- yes
- Remarks:
- methanol
- Statistical methods:
- The decrease in concentration (preliminary test) or the degree of hydrolysis was calculated using the formula:
Degree of hydrolysis in % = [(C0 - Ct)/C0 ] · 100
where:
C0 = concentration of time 0
Ct = concentration of time t - Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on hydrolysis and appearance of transformation product(s):
- Based on the chemical structure of the test item, the hydrolysis products were considered to be benzenesulphonic acid (CAS 98-11-3) and p-toluidine (CAS 106-49-0).
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- not specified
- pH:
- 9
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- > 62.6 d
- Type:
- not specified
- Validity criteria fulfilled:
- yes
- Conclusions:
- Rate constant at pH 9: 4.61 E-4 /hour
Estimated half-life at 25°C at pH 4 and 7: > 1 year
Estimated half-life at 25°C at pH 9: 62.6 days
Reference
Description of key information
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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