Registration Dossier
Registration Dossier
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EC number: 605-254-1 | CAS number: 16142-27-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline and GLP-Study with no or minor deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 5-amino-3-(morpholin-4-yl)-1,2,3-oxadiazolidin-3-ium chloride
- EC Number:
- 605-254-1
- Cas Number:
- 16142-27-1
- Molecular formula:
- C6 H11 N4 O2 . Cl
- IUPAC Name:
- 5-amino-3-(morpholin-4-yl)-1,2,3-oxadiazolidin-3-ium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- > 290 g/L
- Temp.:
- 20 °C
- pH:
- 2.3
Any other information on results incl. tables
The water solubility CS of Sydnonimin/Linsidomin was determined based on the "flask method" described in the European Commission Council regulation (EC) No 440/2008, Annex, Part A, A.6., OECD-guideline 105 and the US EPA Product Properties Test Guideline OCSPP 830.7840. Due to the high solubility of the test item a minimum water solubility was determined by visual estimation.
Two independent sample weights of the test item were dissolved in small amounts of water. The samples were equilibrated at 20°C for 30 minutes. After this period the solutions were checked for undissolved particles. Both test solutions were clear, the test item was dissolved completely. The final volumes of the samples were determined using a measuring cylinder. From the sample weights and the final volumes the minimum solubility was calculated.
The results of the experiments are shown in the following table:
Water solubility of the test substance
Final pH1 CS
Solubility at 20°C2
2.3 > 290 g/L
1 Mean pH – value resulting from two experiments
2 The mean value from both tests was rounded to the next lower ten
The sample purity of 99.5 % (w/w) has been taken into account.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
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