Registration Dossier
Registration Dossier
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EC number: 610-868-8 | CAS number: 52603-48-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 March 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- 5-amino-3-methylthiophene-2,4-dicarbonitrile
- EC Number:
- 610-868-8
- Cas Number:
- 52603-48-2
- Molecular formula:
- C7N3H5S
- IUPAC Name:
- 5-amino-3-methylthiophene-2,4-dicarbonitrile
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 109 mg/L
- Remarks on result:
- other: No information regarding pH provided in study report. Column temperature for HPLC experiment listed as ambient, however no specific value listed.
- Details on results:
- At 300 nm, the peak areas observed for the test substance test solutions were 5320116 and 5595645. Using these values in Equation 1 as y values and solving for x, we obtain water solubility values for the test substance of 106 mg/L and 112 mg/L.
Any other information on results incl. tables
No information regarding pH provided in study report. Column temperature for HPLC experiment listed as ambient, however no specific value listed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
The test compound was found to have a water solubility of 109 mg/L (average of 106 mg/L and 112 mg/L). - Executive summary:
In a water solubility study (20169-45), the water solubility has been determined to be 109 mg/l of solution at ambient temperature by the flask method based on OECD Test Method 105.
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