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Diss Factsheets
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EC number: 485-110-0 | CAS number: 53535-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2007-11-26 to 2007-11-30
- Reliability:
- 1 (reliable without restriction)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 92/69/EEC
- Deviations:
- no
- Principles of method if other than guideline:
- NA
- GLP compliance:
- yes (incl. QA statement)
Test material
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
NA
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- For the analysis of the test item concentrations, samples from the test media of the test concentration and the control were taken at the start and at the end of the test. All test medium samples were taken from the approximate centre of the aquaria without mixing of the test media.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- media according to EU guideline C1, directive 92/69/EEC
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Age and Size: Juveniles; The mean body length of the fish was 2.6 – 3.3 cm. The body length of 10 test animals from the test fish batch were measured prior to the start of the test. The mean body weight of all treated fish was 0.284 g. The body weight of fish was recorded on the day 0 (at the start of the main study). First the weight of a vessel filled with water was determined. Then seven fish were placed into this vessel. The weight of the seven fish was registered and the average body weight was calculated for one fish. On the basis of the above, the loading of the testing liquid in the test-aquaria was calculated (g fish/litre testing liquid). The maximum loading was 0.398 g /L in the test.
For 56 days before the start of the test the fish were acclimated to the test water and test temperature.For 56 days before the start of the test the fish were acclimated to the test water and test temperature.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- NA
Test conditions
- Hardness:
- c(CaCO3) = 169.5 mg/L
- Test temperature:
- 21.9 – 22.7 °C
- pH:
- pH 8.31 to 9.15
- Dissolved oxygen:
- at least 91 % or higher
- Salinity:
- n.a.
- Nominal and measured concentrations:
- Limit Test: 100.0 mg/L (nominal)
The measured concentrations in the test medium were 90 and 84 percent of the nominal concentration. - Details on test conditions:
- NA
- Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The 96-hour NOEC (highest concentration tested without toxic effects after the exposure period of 96 hours) of Lithium-tert-amoxide (LTA) were determined to be greater than 100.0 mg test item/L nominal concentration.
The measured concentrations in the test medium were 90 and 84 percent of the nominal concentration. As the deviation of the measured concentrations from the nominal values was lower than 20 %, all reported biological results are related to the nominal concentration applied in the test. - Results with reference substance (positive control):
- no posititve controle
- Reported statistics and error estimates:
- NA
Any other information on results incl. tables
- Sublethal observations / clinical signs:
There was no mortality in the control and in the test item treated group of nominal 100.0 mg/L.
No symptoms of intoxication were observed in the control group and in the test item treated group of nominal 100.0 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50 (96h) is greater than 100 mg/L.
- Executive summary:
No adverse effects were observed throughout the exposure period. Thus the 96-hour LC50 is considered to be > 100 mg Lithium-tert-amoxide (LTA)/L .
The 96-hour NOEC (highest concentration tested without toxic effects after the exposure period of 96 hours), respectively the 96-hour LC0 of Lithium-tert-amoxide (LTA) were determined to be at least 100.0 mg test item/L nominal concentration.
The NOEC and the LC0 might even be higher than this concentration, but concentrations in excess of 100.0 mg test item/L nominal concentration have not been tested.
The 96-hour LOEC and the 96-hour LC100 were clearly higher than 100.0 mg test item/L nominal concentration.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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